Clinical Effectiveness of High-Intensity Laser in Wound Management: A Systematic Review and Meta-Analysis
DOI:
https://doi.org/10.55324/ijoms.v5i10.1306Keywords:
Magnifica Humanitas, Catholic Social Doctrine, Artificial Intelligence Governance, Babel and Nehemiah, Trinitarian CommunionAbstract
Chronic wounds remain a major healthcare challenge because of their prolonged healing time, increased risk of infection, extended hospitalization, reduced quality of life, and substantial healthcare costs. High-Intensity Laser Therapy (HILT) has emerged as a promising noninvasive intervention that may enhance wound healing by stimulating tissue regeneration, improving microcirculation, promoting collagen synthesis, and accelerating wound closure. This systematic review and meta-analysis aimed to evaluate the efficacy of HILT compared with conventional wound care, standard medical treatment, or sham laser therapy in improving wound-healing outcomes among patients with chronic and delayed-healing wounds. A systematic literature search was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines using the PubMed, Scopus, ScienceDirect, and Google Scholar databases up to May 2026. Eligible studies were selected based on predefined inclusion and exclusion criteria. The methodological quality of the included studies was assessed using the Jadad Scale. Five interventional studies met the eligibility criteria and were included in the systematic review. Of these, three studies provided sufficiently homogeneous quantitative data and were included in the meta-analysis. The pooled analysis demonstrated that HILT significantly reduced wound surface area compared with control interventions (mean difference = ?3.53; 95% confidence interval: ?5.66 to ?1.40; p = 0.001), although substantial heterogeneity was observed among the studies (I² = 96%). In addition, the included studies consistently reported improvements in wound size reduction, wound appearance, wound-healing scores, and overall clinical outcomes following HILT.
References
Ahmed, A.-B., et al. (2025). Platelet-rich plasma (PRP) and recombinant growth factor therapies in cutaneous wound healing: Mechanisms, clinical applications, and future directions. Journal of Clinical Medicine, 14(23), 8583. https://doi.org/10.3390/jcm14238583
Alayat, M. S. (2026). The effectiveness of photobiomodulation therapy on perineal pain and wound healing after episiotomy: A systematic review and meta-analysis. Clinical Medicine.
Fortuna, D. (2025). High-intensity vs. high-power laser therapy: Biophysical implications of a semantic ambiguity and the distinct role of photoacoustic effects. Applied Sciences.
Frykberg, R. G. (2015). Challenges in the treatment of chronic wounds. Comprehensive Invited Review.
Gallagher, K. A., et al. (2024). Current status and principles for the treatment and prevention of diabetic foot ulcers in the cardiovascular patient population: A scientific statement from the American Heart Association. Circulation, 149(4), e232–e253.
Hernández-Bule, M. L., Naharro-Rodríguez, J., Bacci, S., & Fernández-Guarino, M. (2024). Unlocking the power of light on the skin: A comprehensive review on photobiomodulation. International Journal of Molecular Sciences, 25(8), 4483. https://doi.org/10.3390/ijms25084483
Jiang, Y., et al. (2021). Tissue repair and regeneration disorders: Repair and regeneration of chronic refractory wounds. In Regenerative Medicine in China (pp. 139–178). Springer.
Kurhaluk, N. (2026). Photobiomodulation and low-level laser therapy as complementary strategies in diabetes treatment. International Journal of Molecular Sciences.
Lohr, J. M. (2026). A synergistic multimodality treatment approach to address the key drivers of wound chronicity. Journal of Vascular Surgery: Venous and Lymphatic Disorders.
Lu, Q. (2020). Clinical effects of high-intensity laser therapy on patients with chronic refractory wounds: A randomised controlled trial. BMJ Open.
Mussttaf, R. A., Jenkins, D. F. L., & Jha, A. N. (2019). Assessing the impact of low level laser therapy (LLLT) on biological systems: A review. International Journal of Radiation Biology, 95(2), 120–143. https://doi.org/10.1080/09553002.2019.1524941
Nirenjen, S., et al. (2023). Exploring the contribution of pro-inflammatory cytokines to impaired wound healing in diabetes. Frontiers in Immunology, 14, 1216321. https://doi.org/10.3389/fimmu.2023.1216321
Olteanu, G. (2024). Advancements in regenerative hydrogels in skin wound treatment: A comprehensive review. International Journal of Molecular Sciences.
Orti, H. A. (2026). Comparison of the effectiveness of high-intensity laser therapy versus low-level laser therapy in musculoskeletal disorders: A systematic review and network meta-analysis. Lasers in Medical Science.
Pérez, S. E. (2025). Effectiveness of hyperbaric oxygen therapy for musculoskeletal pain syndromes: A systematic review. Muscles.
Peterson, A. (2025). Preventing pressure injuries in individuals with impaired mobility: Best practices and future directions. HHS Public Access.
Pramesti, A. R. (2025). The effect of high intensity laser therapy on low back pain: A literature review. International Journal of Medical Science and Clinical Research Studies.
Redmond, M. C. (2025). A review of chronic wounds and their impact on negative affect, cognition, and quality of life. International Wound Journal.
Rashidi, S., et al. (2015). Laser therapy for wound healing: A review of current techniques and mechanisms of action. Bioscience, Biotechnology Research Asia, 12, 217–223.
Song, J., et al. (2025). Cell migration in diabetic wound healing: Molecular mechanisms and therapeutic strategies. International Journal of Molecular Medicine, 56(2), 126.
Wan, R., et al. (2021). Diabetic wound healing: The impact of diabetes on myofibroblast activity and its potential therapeutic treatments. Wound Repair and Regeneration, 29(4), 573–581. https://doi.org/10.1111/wrr.12942
Yoon, S. H. (2024). The efficacy of high-intensity laser therapy in wound healing: A narrative review. Lasers in Medical Science.
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Copyright (c) 2026 Jeanette R.A. Leo, David S. Perdanakusuma, Ardea Perdanakusuma, Natalia Wahyudi
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