Neuron Specific Enolase Levels’ Relationship with CT Scan Images on Head Injury Patients
DOI:
https://doi.org/10.55324/ijoms.v2i10.572Keywords:
neuron specific enolase, CT scan, head injuryAbstract
Head injuries can cause closed injuries, or open injuries that can penetrate the skin, starting from the skin as the outermost layer, to the bones of the skull, blood vessels of the brain, and brain tissue as cranio-cerebral injuries. The authors wanted to prove whether there is a picture between NSE serum levels and a CT scan of the head that describes the severity of a head injury. The type of research used in this research is analytic observational research. The study design in this study was a cross sectional which aims to describe the levels of Neuron Specific Enolase (NSE) serum with CT scan images of head injured patients at RSUP Dr. M. Djamil City of Padang. This research was conducted in the Emergency Room of RSUP Dr. M. Djamil, Padang City as the sampling location and the Biomedical Laboratory of the Faculty of Medicine, Andalas University as the research location and the research time starts from February to June 2023. Head injury patients who underwent head CT scans at the M.Djamil Hospital Padang Emergency Room were found with the following characteristics: age 20-29 years, male sex, CT scan of the head in the form of MLS<5mm/cistern narrowing, increased NSE level, severity mild head injury (GCS 13-15).
References
Biuki, N. M., Talari, H. R., Tabatabaei, M. H., Abedzadeh - kalahroudi, M., Akbari, H., Esfahani, M. M., & Faghihi, R. (2023). Comparison of the predictive value of the Helsinki, Rotterdam, and Stockholm CT scores in predicting 6-month outcomes in patients with blunt traumatic brain injuries. Chinese Journal of Traumatology. https://doi.org/10.1016/j.cjtee.2023.04.002
Blazer, D. G., Bazarian, J., & Bogner, J. (2019). Evaluation of the disability determination process for traumatic brain injury in veterans. National Academies Press. https://doi.org/10.17226/25317
Cheng, F., Yuan, Q., Yang, J., Wang, W., & Liu, H. (2014). The prognostic value of serum neuron-specific enolase in traumatic brain injury: Systematic review and meta-analysis. PLoS ONE, 9(9), e106680. https://doi.org/10.1371/journal.pone.0106680
Chieregato, A., Martino, C., Pransani, V., Nori, G., Russo, E., Noto, A., & Simini, B. (2010). Classification of a traumatic brain injury: The Glasgow Coma scale is not enough. Acta Anaesthesiologica Scandinavica, 54(6), 696–702. https://doi.org/10.1111/j.1399-6576.2010.02234.x
El-Maraghi, S., Yehia, H., Hossam, H., Yehia, A., & Mowafy, H. (2013). The prognostic value of neuron specific enolase in head injury. The Egyptian Journal of Critical Care Medicine, 1(1), 25–32. https://doi.org/10.1016/j.ejccm.2012.12.002
Faried, A., Bachani, A. M., Sendjaja, A. N., Hung, Y. W., & Arifin, M. Z. (2017a). Characteristics of moderate and severe traumatic brain injury of motorcycle crashes in Bandung, Indonesia. World Neurosurgery, 100, 195–200. https://doi.org/10.1016/j.wneu.2016.12.133
Faried, A., Bachani, A. M., Sendjaja, A. N., Hung, Y. W., & Arifin, M. Z. (2017b). Characteristics of moderate and severe traumatic brain injury of motorcycle crashes in Bandung, Indonesia. World Neurosurgery, 100, 195–200. https://doi.org/10.1016/j.wneu.2016.12.133
Hurley, R. A., McGowan, J. C., Arfanakis, K., & Taber, K. H. (2004). Traumatic axonal injury: Novel insights into evolution and identification. The Journal of Neuropsychiatry and Clinical Neurosciences, 16(1), 1–7. https://doi.org/10.1176/jnp.16.1.1
Jain, S., & Iverson, L. M. (2022, June 21). Glasgow Coma scale. National Library of Medicine: National Center for Biotechnology Information.
Lecky, F. E., Otesile, O., Marincowitz, C., Majdan, M., Nieboer, D., Lingsma, H. F., Maegele, M., Citerio, G., Stocchetti, N., Steyerberg, E. W., Menon, D. K., & Maas, A. I. R. (2021). The burden of traumatic brain injury from low-energy falls among patients from 18 countries in the CENTER-TBI Registry: A comparative cohort study. PLOS Medicine, 18(9), e1003761. https://doi.org/10.1371/journal.pmed.1003761
Miyagawa, T., Saga, M., Sasaki, M., Shimizu, M., & Yamaura, A. (2023). Statistical and machine learning approaches to predict the necessity for computed tomography in children with mild traumatic brain injury. PLoS ONE, 18(1 January). https://doi.org/10.1371/journal.pone.0278562
Mozafari, J., Motamed, H., Hanafi, M. G., & Fatehifar, B. (2020). The diagnostic value of neuron-specific enolase in children with mild blunt trauma requiring cranial CT scan. Open Access Emergency Medicine, Volume 12, 1–5. https://doi.org/10.2147/OAEM.S223179
Mozaffari, K., Dejam, D., Duong, C., Ding, K., French, A., Ng, E., Preet, K., Franks, A., Kwan, I., Phillips, H. W., Kim, D. Y., & Yang, I. (2021). Systematic review of serum biomarkers in traumatic brain injury. Cureus. https://doi.org/10.7759/cureus.17056
Neher, M. D., Keene, C. N., Rich, M. C., Moore, H. B., & Stahel, P. F. (2014). Serum biomarkers for traumatic brain injury. Southern Medical Journal, 107(4), 248–255. https://doi.org/10.1097/SMJ.0000000000000086
Olivecrona, Z., Bobinski, L., & Koskinen, L.-O. D. (2015). Association of ICP, CPP, CT findings and S-100B and NSE in severe traumatic head injury. Prognostic value of the biomarkers. Brain Injury, 29(4), 446–454. https://doi.org/10.3109/02699052.2014.989403
Papa, L., Lewis, L. M., Falk, J. L., Zhang, Z., Silvestri, S., Giordano, P., Brophy, G. M., Demery, J. A., Dixit, N. K., Ferguson, I., Liu, M. C., Mo, J., Akinyi, L., Schmid, K., Mondello, S., Robertson, C. S., Tortella, F. C., Hayes, R. L., & Wang, K. K. W. (2012). Elevated levels of serum glial fibrillary acidic protein breakdown products in mild and moderate traumatic brain injury are associated with intracranial lesions and neurosurgical intervention. Annals of Emergency Medicine, 59(6), 471–483. https://doi.org/10.1016/j.annemergmed.2011.08.021
Pavlovic, D., Pekic, S., Stojanovic, M., & Popovic, V. (2019). Traumatic brain injury: neuropathological, neurocognitive and neurobehavioral sequelae. Pituitary, 22(3), 270–282. https://doi.org/10.1007/s11102-019-00957-9
Pelinka, L. (2004). Serum markers of severe traumatic brain injury: Are they useful? Indian Journal of Critical Care Medicine, 8(3).
Prawiroharjo, P., Pangeran, D., Supriawan, H., Lastri, D., Mayza, A., Zairinal, R. A., Dewi, A. R., Asmaniar, F., & Ramli, Y. (2020). Increasing traumatic brain injury incidence during COVID-19 pandemic in the Emergency Department of Cipto Mangunkusumo National General Hospital—A national referral hospital in Indonesia. Neurology, 95(20 Supplement 1), S11.1-S11. https://doi.org/10.1212/01.wnl.0000719968.10580.81
Schiff, L., Hadker, N., Weiser, S., & Rausch, C. (2012). A literature review of the feasibility of glial fibrillary acidic protein as a biomarker for stroke and traumatic brain injury. Molecular Diagnosis & Therapy, 16(2), 79–92. https://doi.org/10.1007/BF03256432
Su, Y. R. S., Veeravagu, A., & Grant, G. (2016). Neuroplasticity after traumatic brain injury. In Translational Research in Traumatic Brain Injury (pp. 186–201). CRC Press. https://doi.org/10.1201/b18959-13
Sukorini, U., Wulandari, I. S., Mulyono, B., & Pramusinto, H. (2018). Korelasi antara neuron-specific enolase serum dan glasgow coma scale di pasien cedera kepala. Indonesian Journal of Clinical Pathology and Medical Laboratory, 17(1), 25–31. https://doi.org/10.24293/ijcpml.v17i1.1043
Sun, Y., Wang, S., Gan, S., Niu, X., Yin, B., Bai, G., Yang, X., Jia, X., Bai, L., & Zhang, M. (2021). Serum neuron-specific enolase levels associated with connectivity alterations in anterior default mode network after mild traumatic brain injury. Journal of Neurotrauma, 38(11), 1495–1505. https://doi.org/10.1089/neu.2020.7372
Syafrita, Y., & Fitri, N. (2021). Analysis of neuron specific enolase serum levels in traumatic brain injury. Bioscientia Medicina: Journal of Biomedicine and Translational Research, 5(4), 381–386.
Thelin, E. P., Jeppsson, E., Frostell, A., Svensson, M., Mondello, S., Bellander, B.-M., & Nelson, D. W. (2016). Utility of neuron-specific enolase in traumatic brain injury; relations to S100B levels, outcome, and extracranial injury severity. Critical Care, 20(1), 285. https://doi.org/10.1186/s13054-016-1450-y
Thelin, E. P., Nelson, D. W., Vehviläinen, J., Nyström, H., Kivisaari, R., Siironen, J., Svensson, M., Skrifvars, M. B., Bellander, B.-M., & Raj, R. (2017). Evaluation of novel computerized tomography scoring systems in human traumatic brain injury: An observational, multicenter study. PLOS Medicine, 14(8), e1002368. https://doi.org/10.1371/journal.pmed.1002368
Wee, J., Yang, Y., Lee, Q., Cao, K., & Chong, C. (2016). Demographic profile and extent of healthcare resource utilisation of patients with severe traumatic brain injury: still a major public health problem. Singapore Medical Journal, 57(09), 491–496. https://doi.org/10.11622/smedj.2015162
Downloads
Published
Issue
Section
License
Copyright (c) 2023 Hary Romeo Imanharibsar
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-ShareAlike 4.0 International (CC-BY-SA). that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
