Molecular and Histological Changes in Airway Basal Stem Cells on Chronic Obstructive Pulmonary Disease
DOI:
https://doi.org/10.55324/ijoms.v2i10.586Keywords:
COPD, airway epithel, airway basal cell, stem cellAbstract
Airway basal stem cell changes in COPD including hyperplasia, squamous cell metaplasia, epithel-mesenchymal transision, impairment of cillia and secretoric non mucosal cell differentiation, and junctional barrier integrity disturbances that lead to histological changes. There are also molecular changes such as disturbances in gene expresion, cytokines, inflamation factor and dysregulation of basal cell transcriptome in locus 19q13.2. This article is aimed to review airway basal cell changes in COPD. By understanding initial changes of airway basal stem cell in COPD, hopefully can help to develop stem cell therapy in COPD treatment. The research aims to explore molecular and histological changes in airway basal stem cells on chronic obstructive pulmonary disease. The researchers used literature review as the way to verify their arguments on the issue discussed by analyzing the results of scientific sources, especially from trusted sources such as Google Scholar and Science Direct. The study continues by stating that regenerative therapy using stem cells has started to evolve with the advancement of stem cell technology and is anticipated to improve and treat this illness. Only preclinical and phase 2 clinical trials have seen recent advancements in the use of stem cells for treating COPD.
References
Amatngalim, G. D., & Hiemstra, P. S. (2018). Airway epithelial cell function and respiratory host defense in chronic obstructive pulmonary disease. Chinese Medical Journal, 131(09), 1099–1107.
Balkissoon, R. (2018). Stem cell therapy for COPD: Where are we? Chronic Obstructive Pulmonary Diseases, 5(2). https://doi.org/10.15326/JCOPDF.5.2.2018.0140
Berg, K., & Wright, J. L. (2016). The pathology of chronic obstructive pulmonary disease: progress in the 20th and 21st centuries. Archives of Pathology & Laboratory Medicine, 140(12), 1423–1428.
Brandsma, C. A., Van den Berge, M., Hackett, T. L., Brusselle, G., & Timens, W. (2020). Recent advances in chronic obstructive pulmonary disease pathogenesis: from disease mechanisms to precision medicine. In Journal of Pathology (Vol. 250, Issue 5). https://doi.org/10.1002/path.5364
Cao, X. Y., & Xiao, S. Y. (2018). Chronic lung disease, lung regeneration and future therapeutic strategies. Chronic Diseases and Translational Medicine, 4(2). https://doi.org/10.1016/j.cdtm.2018.05.001
Crystal, R. G. (2014). Airway basal cells: The “smoking gun” of chronic obstructive pulmonary disease. American Journal of Respiratory and Critical Care Medicine, 190(12), 1355–1362.
Global Initiative for Chronic Obstructive Lung Disease. (2018). Pocket guide to COPD diagnosis, management, and prevention: A guide for health care professionals. Global Initiative for Chronic Obstructive Lung Disease.
IHME. (2023). Measuring what matters: Indonesia. IHME.
Mescher, A. L. (2000). Junquiera’s basic histology. McGraw-Hill.
Mirza, S., Clay, R. D., Koslow, M. A., & Scanlon, P. D. (2018). COPD guidelines: A review of the 2018 GOLD report. Mayo Clinic Proceedings, 93(10). https://doi.org/10.1016/j.mayocp.2018.05.026
Oh, D. K., Kim, Y. S., & Oh, Y. M. (2017). Lung regeneration therapy for chronic obstructive pulmonary disease. Tuberculosis and Respiratory Diseases, 80(1). https://doi.org/10.4046/trd.2017.80.1.1
Rock, J. R., Randell, S. H., & Hogan, B. L. M. (2010). Airway basal stem cells: A perspective on their roles in epithelial homeostasis and remodeling. Disease Models & Mechanisms, 3(9–10), 545–556.
Ryan, D. M., Vincent, T. L., Salit, J., Walters, M. S., Agosto-Perez, F., Shaykhiev, R., Strulovici-Barel, Y., Downey, R. J., Buro-Auriemma, L. J., Staudt, M. R., Hackett, N. R., Mezey, J. G., & Crystal, R. G. (2014). Smoking dysregulates the human airway basal cell transcriptome at COPD Risk Locus 19q13.2. PLoS ONE, 9(2), e88051. https://doi.org/10.1371/journal.pone.0088051
Shaykhiev, R., & Crystal, R. G. (2014). Early events in the pathogenesis of chronic obstructive pulmonary disease. Smoking-induced reprogramming of airway epithelial basal progenitor cells. Annals of the American Thoracic Society, 11(Supplement 5), S252–S258.
WHO. (2009). Country profiles of environmental burden disease: Indonesia. WHO.
Downloads
Published
Issue
Section
License
Copyright (c) 2023 A. A. Ayu Asri Prima Dewi, Rizqa Inayati, Komang Trisna Sumadewi, Fransiscus Fiano Anthony Kerans
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-ShareAlike 4.0 International (CC-BY-SA). that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
